This presentation highlights how integrated structural biology and biophysical techniques enable more efficient and rational drug discovery. By combining Cryo‑EM, X‑ray crystallography, NMR, and HDX‑MS, Novalix delivers a comprehensive understanding of biomolecular structure, dynamics, and interactions. These structural insights transform drug discovery from a trial‑and‑error process into a precision‑driven strategy, supporting improved target validation, accelerated lead optimization, and reduced attrition.​

Each technique provides complementary strengths: Cryo‑EM enables the study of large macromolecular assemblies, X‑ray crystallography provides high‑resolution atomic detail, NMR supports the analysis of small proteins and low‑affinity fragments, and HDX‑MS reveals protein dynamics and addresses targets that are challenging for other approaches. Together, they generate a complete and actionable view of drug–target mechanisms.​

At Novalix, integrated workflows accelerate every stage of discovery from rational construct design and biophysical characterization to fragment screening and lead optimization, including challenging targets such as membrane proteins and protein–protein interactions. Seamless transitions between techniques minimize bottlenecks when individual methods reach their limits, reducing risk and avoiding project delays. This integrated approach delivers measurable impact, enabling faster timelines and improved success rates.​

Key Topics:

• Understand the fundamentals and practical workflows of Cryo‑EM, X‑ray, NMR, and HDX‑MS​


• Learn how each technique’s strengths and limitations influence drug discovery strategies​


• Discover real case studies demonstrating how integrated approaches outperform single techniques​


• See how combining methods unlocks a holistic view of structure, dynamics, and interactions​