About
Get an exclusive first look at BrainXell’s newly launched human iPSC-derived sensory neurons and learn how they enable reproducible, human-relevant models for sensory transduction, pharmacology, and ion channel research.

Be among the first to explore BrainXell’s recently launched human iPSC-derived sensory neurons and learn how this new platform is advancing human-relevant models for sensory biology research and drug discovery. Human sensory neuron models are increasingly essential for advancing translational neuroscience research, particularly in pain biology, sensory transduction, and ion channel pharmacology. Traditional model systems often lack human-specific biology or reproducibility at scale, limiting predictive insight during drug discovery workflows. BrainXell’s sensory neurons are designed to address these challenges through controlled differentiation, scalable manufacturing, and stringent quality control processes that support consistent experimental outcomes across studies.

In this webinar, BrainXell scientists will present comprehensive characterization data demonstrating neuronal maturation, robust marker expression, functional responsiveness to canonical agonists, electrophysiological activity, and pharmacological specificity. Attendees will gain insight into how these neurons support applications including sensory transduction studies, ion channel screening, and pharmacological validation using physiologically relevant human models. Functional responses to ATP, capsaicin, icilin, histamine, and thermal stimuli highlight the platform’s utility for discovery and translational research programs.

Key Topics:

  • How human iPSC-derived sensory neurons mature post-thaw and develop functional neuronal networks within 3–4 weeks.

  • Key marker expression profiles including NaV1.7, NaV1.8, NaV1.9 sodium channels and TRPV1/TRPM8 sensory transduction markers.

  • How functional assays demonstrate pharmacological specificity through agonist and antagonist responses.

  • Applications of electrophysiology and MEA readouts for evaluating neuronal activity and ion channel modulation.

  • Best practices for integrating reproducible human sensory neuron models into screening and drug discovery workflows.

Presenters
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Semra Sahin, PhD
Applications Scientist, BrainXell
Semra Sahin, PhD is an Applications Scientist at BrainXell, where she supports the development and application of human iPSC-derived neuronal and glial models for neuroscience research and drug discovery. With a background in neuroscience, molecular biology, and cellular biology, she brings extensive experience in neuronal differentiation, functional characterization, and advanced in vitro assay development. Prior to joining BrainXell, Dr. Sahin conducted academic research focused on neuronal development and synaptic biology, contributing peer-reviewed publications and presenting her work at international scientific conferences. At BrainXell, she collaborates with researchers to translate complex experimental needs into practical, human-relevant cell model solutions.
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Matt Mandeville
Business Development, BrainXell
Matthew Mandeville is a Business Development professional at BrainXell, where he works closely with biotechnology and pharmaceutical partners to support the adoption of human iPSC-derived cell models for neuroscience research and drug discovery. Based in the Greater Boston area, Matt focuses on building collaborative relationships with researchers and organizations seeking physiologically relevant human cell platforms and assay solutions. He brings experience in scientific engagement, customer partnerships, and translating complex research needs into practical solutions that advance translational neuroscience programs.
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Neuroscience
Drug Discovery & Screening
Pharmacology & Toxicology
Pain & Sensory Biology
Stem Cell Biology / iPSCs
Cellular & Molecular Biology
Translational Medicine
Genetic & Rare Diseases
Electrophysiology & Bioengineering
Developmental Biology
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