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Name
April Pyle
Title
Adventures in ex vivo and in vivo muscle stem cell gene editing
Bio
Dr. Pyle is a Professor and Vice Chair in the Department of Microbiology, Immunology and Molecular Genetics, and a member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research (BSCRC) at UCLA. Dr. Pyle's lab uses multi-disciplinary approaches to study muscle stem cells, human pluripotent stem cells and differentiation. Dr. Pyle's lab studies both basic aspects of stem cell biology, reprogramming, and muscle development as well as more translational aspects to develop therapeutic approaches for patients with Duchenne Muscular Dystrophy (DMD). The lab is interested in developing ex vivo and direct in vivo CRISPR correction stem cell strategies for DMD. Dr. Pyle is also co-founder of MyoGene Bio which aims to develop a therapeutic CRISPR/Cas9 platform platform designed to restore the reading frame of the DMD gene.
