Webinar: Indirect Calorimetry for Rodent Research: New Approaches to Enhance Translational Value by InsideScientific

Indirect Calorimetry for Rodent Research: New Approaches to Enhance Translational Value

About

In this webinar, Professors John Speakman and Emma Slack each present research from their labs conducted with novel modules of the PhenoMaster which increases the translational value of rodent indirect calorimetry.

Prof. John Speakman: Maximising Translation of Mouse Calorimetry to Humans

Human calorimetry is founded on two different technologies. Room calorimetry which enables measures of 24h energy demands, and hood calorimetry which measures just the resting energy demands. The systems currently available for rodents mimic the room calorimeters. However, there is no equivalent system to the hood calorimeter. In the first portion of the webinar, Prof. Speakman introduces the TSE Systems’ PhenoMaster platform and how it mimics room calorimetry systems and then introduces a new chamber design that his group have developed with TSE systems to mimic the hood calorimeter, along with some preliminary data from this system.

Prof. Emma Slack: Real-time Analysis of Gut Microbiome Function

Every internal and external body surface of an animal hosts a microbial consortium. The density, diversity and dynamics of these consortia vary over many orders of magnitude. In some cases, particularly in insects, a single microbial species is found in almost all members of a host species. In others, such as humans, shared microbiota species seem to be an exception rather than a rule. Nevertheless, the importance of these consortia for the health of the host is increasingly recognized. Major questions remain over how microbiota composition influences health, but a major axis is clearly via metabolic exchange. In the second portion of the webinar, Prof. Slack introduces work using isolator-housed TSE PhenoMaster systems for metabolic analysis of animals with zero microbiomes, as well as the use of secondary electrospray ionization mass spectrometry and novel sensor design to expand the functionality of these systems.

Key Topics:

Rodent indirect calorimetry and its applications

Indirect calorimetry under highest hygienic standards

Microbiota and impact on health

Calorimetric measurement under defined gut microbiome conditions

Presenters

Prof. John Speakman

Professor, Chinese Academy of Sciences, Shenzhen, School of Biological Sciences, University of Aberdeen, UK

Dr. John Speakman, a British biologist, is the Director of the Shenzhen Key Laboratory of Metabolic Health at the Chinese Academy of Sciences in Shenzhen, China and serves as a professor in the School of Biological Sciences at the University of Aberdeen in Scotland. His research focuses on energy balance, exploring factors influencing food intake and energy expenditure, and their implications for fat storage (obesity) and other physiological parameters such as oxidative stress and aging.

Prof. Emma Slack

Professor, Institute of Food, Nutrition and Health (D-HEST), ETH Zurich

Emma Slack is a Full Professor for Mucosal Immunology in the Institute of Food, Nutrition and Health (D-HEST) ETH Zurich. Her group develops methodologies to study the within-host population dynamics of intestinal bacteria and applies these to better understand interactions between diet, the immune system and the intestinal microbiota.

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