Webinar: Improving Confidence in Thyroid Hormone Disruption Assessment Using a Novel Human-Relevant In Vitro Model by InsideScientific

Improving Confidence in Thyroid Hormone Disruption Assessment Using a Novel Human-Relevant In Vitro Model

About

Learn how an emerging NAM is helping advance more efficient, human-relevant strategies for assessing thyroid hormone disruption while reducing reliance on animal testing.

Endocrine-disrupting chemicals present a growing global health concern, with the potential to interfere with critical hormonal systems such as thyroid function. However, current approaches to evaluating thyroid toxicity often rely on resource-intensive animal studies or in vitro methods that do not fully capture human-relevant biology.

In this webinar, Chad Deisenroth introduces advances in a new approach method (NAM) for thyroid toxicity testing, with a focus on a human-relevant in vitro model (Human 3D Thyroid Microtissue) that enables direct assessment of thyroid hormone synthesis.

Attendees will gain insight into how this model addresses key limitations in traditional testing strategies by improving biological relevance, reproducibility, and scalability. The session also highlights how recent validation efforts have strengthened confidence in this approach, supporting its application in screening workflows for endocrine-disrupting chemicals.

Key Topics:

Global Health Risk: Endocrine-disrupting chemicals are widespread and threaten human health by interfering with hormonal systems.

Screening Bottleneck: Current hazard identification relies on resource-intensive animal testing, which is too slow and costly to address the vast chemical landscape.

Innovative Solution: Human thyroid microtissues provide a faster, biologically relevant alternative for regulatory thyroid toxicity screening.

Presenter

Chad Deisenroth, PhD

Principal Laboratory Toxicologist, Center for Chemical Informatics and Screening, UL Research Institutes' Chemical Insights

Dr. Chad Deisenroth is a Principal Laboratory Toxicologist in the Center for Chemical Informatics and Screening at UL Research Institutes' Chemical Insights. He earned his Ph.D. in Genetics and Molecular Biology from the University of North Carolina at Chapel Hill and completed postdoctoral training in chemical safety sciences at The Hamner Institutes for Health Sciences.

Prior to joining UL Research Institutes, Dr. Deisenroth served as a principal investigator in the Center for Computational Toxicology and Exposure at the U.S. Environmental Protection Agency, where he advanced the development and application of in vitro new approach methods - or NAMs - for predictive toxicology. His work at the EPA centered on engineering human-relevant cell culture models and innovative testing approaches to improve the speed, reliability, and biological relevance of chemical hazard identification for human health effects.

Dr. Deisenroth has authored numerous peer‑reviewed publications in leading toxicology journals and received recognition for several high‑impact contributions in the field of in vitro toxicology. He has also led U.S. efforts to validate NAM technology in collaboration with international partners and currently contributes to an OECD working group focused on standardizing and implementing NAMs for endocrine toxicity testing.

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