Continuous processing is already well accepted on the upstream processing side since perfusion mode culture has been in use for decades at an industrial scale. Justifications for switching from batch to continuous chromatography are numerous.

Besides, the rising demand for biologics suggests reduced processing and labor costs, footprint reduction, flexibility increase, more stringent requirements for controlled, more consistent and improved quality; and most importantly, the requirement for higher productivity and therefore overall manufacturing cost reduction. Last but not least regulators are pushing for continuous processing.

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