Bone turnover markers were formerly the preserve of research studies, but are increasingly being used in the clinic to monitor response to therapy, aid management decision and to monitor during treatment holidays.

In this lecture there will be a brief overview of bone metabolism and an introduction to some of the most widely used bone turnover markers. Their clinical uses will be described and illustrated with case studies including response to treatment, how different treatments affect them and withdrawal responses including densoumab. Special cases such as renal failure will also be touched upon and their variability.
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    Dr Stephen Tuck
    Consultant Rheumatologist, James Cook University Hospital, Middlesbrough & Honorary Senior Lecturer, Institute of Cellular Medicine, Newcastle University

    Dr Tuck attended Leeds University where he completed a biochemistry degree before qualifying from the Medical School in 1993. He did his specialist training in Rheumatology on the Northern Deanery rotation and was appointed Consultant Rheumatologist in Middlesbrough in 2004.

    He undertook an MD with Professor Francis in Newcastle into the pathogenesis of low trauma fractures and osteoporosis in men, which was awarded in 2007. In 2011 he was appointed Honorary Senior Lecturer at Newcastle University. He has published widely on osteoporosis and continues to undertake research including on forearm fractures in men. He is the Vice Chairman of the Paget’s Association, Editor of Osteoporosis Review and serves on the research grants and clinical and scientific committees for the Royal Osteoporosis Society.

    He is Trust Lead for Metabolic Bone Disease and Chair of the North East regional advisory board.