Dr Farquhar-Smith works at the Royal Marsden NHS Foundation Trust in pain medicine and anaesthesia. He has interests in persistent post-surgical pain and chemotherapy induced peripheral neuropathy, and runs a dedicated CIPN.

He speaks nationally and internationally and is a module lead for the UCL MSc Pain Course. Paul has advised on guidelines including NICE, ICD-11, and London Cancer Vanguard. He is on the editorial board of British Journal of Pharmacology, and he is Editor of Cancer Pain in Current Opinion in Supportive Palliative Care. He is a section head for the f1000 educational website.

He has published over 80 peer reviewed original articles, chapters and letters on pain, intensive care and anaesthesia.