Traditional toxicology approaches rely heavily on animal testing, which limits throughput and human relevance. Recent advances in microphysiological system (MPS) platforms allow multiple human organ models to be linked to provide toxicokinetic data while reducing reliance on in vivo studies. The kinetic, metabolism and toxicity data from MPS models can used to build quantitative models designed to improve generation risk assessment (NGRA).

In this webinar, James McKim and Kaushal Joshi will discuss a study evaluating a model compound in an integrated intestine–liver–kidney MPS, highlighting how in vitro ADMET data align with in vivo reports.

Topics to be covered:

The need for new toxicological methods, particularly for repeated dose toxicity
Design and use of a simulated blood flow system to connect multiple organ compartments
Determining fluid volumes and tissue mass to support multiple timepoint sampling
Application of MPS platforms as new approach methodologies to enhance NGRA