Alessandro Sette, DSc
Professor and Member, Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology
Alessandro Sette has experience in biotech and academia investigating immune responses and developing disease intervention strategies against cancer, autoimmunity, allergy, and infectious diseases. Sette's research group focuses on epitopes. Sette oversaw the design and curation of the national Immune Epitope Database, a freely available, widely used bioinformatics resource that catalogs all human and animal epitopes for allergens, infectious diseases, autoantigens, and transplants, and includes epitope prediction tools that accelerate immunology research around the world. Sette’s research group uses their knowledge of epitopes to define the hallmarks of a beneficial immune response associated with effective vaccines. Sette’s infectious disease interests include SARS-CoV-2, dengue, Zika Chikungunya, herpesviruses, poxviruses, Lassa fever, HIV, and hepatitis viruses, and bacterial pathogens such as tuberculosis and Bordetella pertussis. Sette earned his doctorate in biological sciences from the University of Rome and completed his postdoctoral training at the National Jewish Center for Immunology and Respiratory Medicine in Denver, Colorado. In 1988, Sette joined Cytel in La Jolla, and was appointed adjunct assistant professor at The Scripps Research Institute. He founded Epimmune in 1997, where he served both as vice president of research and chief scientific officer until 2002 when he joined LJI as the head of the Division of Vaccine Discovery. Sette also heads the Center for Infectious Disease at LJI.