Base editors are a new class of CRISPR-Cas9 gene editing agents for modifying genomes in experimental systems. Research efforts have broadened their editing capabilities, expanded their targeting scope, and improved editing specificity. In this webinar, experts will discuss cytosine and adenosine base-editors to introduce point mutations in DNA strands without creating a breakpoint, and opportunities and considerations for using them.
Topics to be covered
• How to chemically change one base to another without affecting DNA stability
• Advantages of base editors over traditional gene-editing tools
• The clinical application of CRISPR base editors
Audrone Lapinaite, PhD
Assistant Professor, School of Molecular Sciences, Arizona State University
Audrone Lapinaite is an assistant professor in the Neurodegenerative Disease Research Center at the Arizona State University. Lapinaite received her PhD in structural biology from the EMBL, Heidelberg, and postdoctoral training as an HFSP postdoctoral fellow at the University of California, Berkeley under the mentorship of Jennifer Doudna and Jamie Cate. She researches the underlying mechanisms of RNA-protein interactions and post-transcriptional RNA processing in neurons in normal and pathological conditions using state-of-art structural and molecular biology approaches, including CRISPR-Cas-mediated DNA and RNA editing. She is also characterizing and harnessing bacterial defense systems such as CRISPR-Cas and restriction-modification for biotechnological and therapeutic applications.
Omar Abudayyeh, PhD
Principal Investigator, Fellow, McGovern Institute for Brain Research, Massachusetts Institute of Technology
Omar Abudayyeh is an independent fellow at the McGovern Institute for Brain Research at MIT. Abudayyeh did his MD/PhD training under the mentorship of Feng Zhang at the Harvard Medical School and the Harvard-MIT Program in Health Sciences and Technology. His research work centered on novel CRISPR enzymes for applications in genome editing, therapeutics, and diagnostics. In recognition of his technology developments, Abudayyeh was placed on the 2018 Forbes 30 Under30 in Science list. His lab applies these new gene-editing tools for treating genetic diseases via gene therapy and studying the biology of aging.