Monoclonal antibodies have been instrumental in treating infectious diseases, including those caused by the Zika virus, the Ebola virus, and most recently, SARS-CoV-2. Since their discovery in the 1970s, scientists have developed improved approaches to identify, select, optimize, and manufacture monoclonal antibodies. This webinar will examine ways that scientists discover and use monoclonal antibodies for the treatment of infectious diseases and discuss exciting developments in monoclonal antibody research.

Topics to be covered

-Rapid technologies for discovery of human monoclonal antibodies for emerging
infections
-Genetic and structural basis of virus neutralization by human monoclonal antibodies
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    James E. Crowe, Jr., MD, PhD
    Director, Vanderbilt Vaccine Center Professor, Pediatrics and Pathology, Microbiology and Immunology Ann Scott Carrell Chair, Vanderbilt University
    James Crowe is the director of the Vanderbilt Vaccine Center, a professor of Pediatrics, Pathology, Microbiology, and Immunology, and the Ann Scott Carell Chair of the Vanderbilt University Medical Center. His laboratory group studies the human immune response to infection for a variety of major human pathogens, including emerging infections. He is the director of the Human Immunome Project, an ambitious effort to identify the sequence of all transcripts for human adaptive immune receptors. He is an elected member of the National Academy of Medicine and the National Academy of Inventors. His research group uses a broad array of techniques including molecular and cellular biology, state-of-the-art imaging and flow cytometry, bioinformatics, and bioengineering approaches to attack scientific problems at the forefront of immunity research. Crowe’s group has been widely recognized as a leader in antibody sciences, receiving awards such as the Best Academic Research Team as part of the 11th Annual Vaccine Industry Excellence Awards at the World Vaccine Congress, the 2019 Merck Future Insight Prize for Pandemic Preparedness, and large-scale research grants and contracts from the NIH and DoD, including the DARPA Pandemic Prevention Program (P3).