Webinar: Skeletal Muscle Circadian Clocks: Keeping Time for Systemic Health by InsideScientific

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Skeletal Muscle Circadian Clocks: Keeping Time for Systemic Health

About

Dr. Karyn Esser presents the critical role of skeletal muscle circadian clocks in maintaining muscle strength, metabolic health, and systemic adaptations to endurance exercise.

Circadian clocks are ~24hr molecular timers that exist in virtually all cells in the body, and they function to support cell, tissue and systemic homeostasis. This session will cover the preclinical and clinical data supporting the role for circadian clocks in skeletal muscle homeostasis through management of pathways important for maintenance of muscle strength and metabolic flexibility. In addition, this session will cover studies demonstrating the important role for skeletal muscle clocks as a key modulator of known healthy adaptations to endurance exercise. Lastly, the discussion will integrate changes in muscle clocks, muscle health as important contributors to systemic, non-muscle tissue health.

Key Topics:

Define the molecular organization and logic of circadian clocks

Delineate mechanisms by which circadian clocks regulate skeletal muscle homeostasis (strength and metabolism)

Dissect the interaction between skeletal muscle clocks and endurance exercise adaptations

Interpret circadian modulation as a mechanistic variable in experimental and translational study design

Presenter

Karyn Esser, PhD

Professor and Chair of Physiology and Aging, University of Florida

Dr. Karyn Esser is Professor and Chair of Physiology and Aging at the University of Florida. Her lab helped establish circadian clocks in skeletal muscle and their role in maintaining strength and metabolic flexibility. Her work examines muscle clocks as components of exercise responses, aging and chronic diseases.

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Drosophila

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Rats

Swine

Dogs

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