About
Join BioModels’ Scientists, Andrew Borkowski, PhD and Nicole Smith, PhD, as they discuss a selection of key preclinical models of inflammatory disease.

Predominantly inflammation driven diseases like acute lung injury, asthma, Crohn’s Disease, Ulcerative Colitis and Graft vs Host Disease (GvHD) impact a large and diverse patient population and present a major opportunity for innovation in drug discovery. In this webinar, Drs. Andrew Borkowski and Nicole Smith discuss preclinical models, including models of Inflammatory Bowel Disease (IBD)/colitis, GvHD, and pulmonary disease, focusing on the utility of clinically relevant endpoints that create highly translational models of human disease.

BioModels has spent over 25 years optimizing disease modeling approaches in these (and other) indications to support our pharmaceutical and biotech clients in their efforts to bring novel therapies to the clinic. Our goal is to provide personalized service and consultation to design and execute the most predictive modeling experiments to support your research programs.

Key learning objectives include:
  • Learn about translational and predictive animal models of Inflammatory Bowel Disease (IBD), Graft versus Host Disease (GVHD), and pulmonary disease

  • Understand the basic components of a successful and comprehensive study design in these therapeutic areas

  • Review the typical disease induction approach, disease kinetics, responses to standard of care therapies, and standard endpoints/outcomes that are assessed in these models

  • Understand how you can work with BioModels to support your drug development efforts using either established disease models or validating new models and endpoints
Presenters
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Andrew Borkowski, PhD
Principal Scientist
Dr. Borkowski joined Biomodels in 2017 after completing his postdoctoral studies in the department of Immunology and Microbial Science at The Scripps Research Institute. His postdoctoral work focused on novel mechanisms of wound healing based on the recognition of lipid antigens in the skin. Andrew received his Ph.D. in Biomedical Sciences from the University of California, San Diego in 2014, where he discovered a role for toll-like receptor 3 in skin permeability barrier repair. Dr. Borkowski has diverse interests in the field of immunology and currently works on inflammatory, fibrotic, and pulmonary disease models.
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Nicole Smith, PhD
Senior Scientist II
Dr. Smith joined Biomodels in 2017 after completing her postdoctoral work at Massachusetts General Hospital. Her work focused on understanding the relationship between checkpoint inhibitor expression patterns and the functional capabilities of tumor-infiltrating lymphocytes. Nicole received her Ph.D. from Boston University School of Medicine in 2016, where she developed a novel murine model that enabled the study of heterotypic adaptive immune memory responses, and using this model identified a novel lung localization pattern for antigen-specific, tissue-resident memory Th17 cells. Dr. Smith is interested in model development and diverse pre-clinical indications, currently focusing on IBD, arthritis, and mucositis.
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