About
While Phage Display panning on naïve libraries combined with costly affinity maturation strategies have allowed the successful development of neutralizing antibodies, it also leads to failures and aborted projects. One reason for this is the immune tolerance of a naïve library that is sometimes ineffective at identifying binders against important and/or highly expressed human targets. An efficient way to access high-affinity, fully human antibodies against such targets is thus essential for human cancer therapy.

In this webinar, Conor will discuss innovative technologies to develop such antibodies using human phage display. These strategies include:
  • A cross-panning protocol for a successful identification of neutralizing binders.

  • Phage display libraries to allow an efficient identification of neutralizing binders through competitive ELISA.

  • A new human cancer library constructed from the PBMCs of cancer patients as an efficient solution to counter immune tolerance.


Key Topics Include:
  • Efficient identification of neutralizing antibodies

  • Strategic development of human phage libraries to break immune tolerance

  • Strategies to augment phage display-based discovery
    • Presenter
    1694207586-425d3838170ae4ee
    Conor McCartin, PhD
    Account Manager - Monoclonal Antibody Development, ProteoGenix
    A Biotechnology graduate from the University of Galway, Ireland, Conor’s studies widened into the domain of Chemical Biology when he moved country to study for his master’s degree in the renowned Chemistry Faculty of the University of Strasbourg, France. From here, he continued to apply his interdisciplinary knowledge from these studies, as well as from several internships in fundamental cancer research, to his Ph.D. focused on developing and studying the mechanisms of new metal-based anti-cancer stem cell chemotherapeutics. This thesis partially revealed the mechanisms of interesting anti-cancer stem cell candidate molecules (described through four publications) and has been honored by prizes from both the Biological Society of Strasbourg and the University of Strasbourg. Since the conclusion of this Ph.D., Conor has since given leave to bench work in order to join ProteoGenix as an Account Manager focused on research and development of monoclonal antibodies.
    Register To Watch Recording
    First Name*
    Last Name*
    Email Address*
    Business Phone
    Country / Region*
    Organization / Company*
    Job Title*
    Main Application Area(s)*
    Cancer
    Infectious Disease
    Therapeutic antibody development
    Autoimmune Disease
    Phage Display
    Other:
    Other application area:
    utm_bmcr_source
    Do you have any specific needs?*
    Antibody discovery
    Antibody engineering
    Antibody or protein production
    Stable cell line development
    ELISA kit development
    Peptide synthesis
    Gene synthesis
    Ready-to-use bioreagents
    None of the above
    Have you heard of ProteoGenix before this event?*
    Yes
    No
    Have a question for Conor? Ask it here:
    Registration Terms
    This event is hosted by the Scientist.com family of companies. Specific brands and sites associated with this event include InsideScientific. By registering and participating, you acknowledge that your personal data will be processed by the webinar platform (BigMarker) and Scientist.com. You also agree to receive email communication from InsideScientific about this webinar and other programs of similar nature. The sponsor of this webinar is ProteoGenix; by registering and participating, you acknowledge that your data will be processed in accordance with ProteoGenix's Privacy Policy. You will receive email communication from ProteoGenix about this webinar and programs of similar interest. You can withdraw your consent at any time from these communications.
    Scientist.com Privacy Policy
    ✓ Yes, I consent to the registration terms.*
    ProteoGenix Privacy Policy
    ✓ Yes, I consent to the registration terms.*
    We use BigMarker as our webinar platform. By clicking Register, you acknowledge that the information you provide will be transferred to BigMarker processing in accordance with their Terms of Service and Privacy Policy.
    Powered by BigMarker