Join Dudley Lamming, PhD to learn how the specific composition of dietary protein and exercise influence metabolic health and aging.

Low protein (LP) diets promote health and longevity in diverse species, and Dr. Lamming's lab have previously shown that reducing dietary levels of the three branched-chain amino acids (BCAAs) leucine, isoleucine, and valine recapitulates many of these benefits in young C57BL/6J mice. Notably, each BCAA has unique metabolic effects, and restriction of isoleucine is both sufficient to promote metabolic health and required for the metabolic benefits of an LP diet in C57BL/6J males.

In this webinar, Dr. Lamming demonstrates that specifically restricting dietary isoleucine alone reprograms metabolism, reduces frailty, and extends the lifespan of both male and female HET3 mice, but to a much greater degree in males. He also examines the paradoxical effect of protein on metabolic health, and finds that while in sedentary mice protein promotes fat gain, mice engaged in resistance exercise training are protected from fat gain, build larger muscles, and gain increased strength. Finally, the results demonstrate that metabolic health and aging are mediated not simply by the number of calories we eat, but by the specific composition of the dietary protein and by exercise.

Key Topics:

• Restricting specific dietary amino acids can promote metabolic health in mice.


• Reducing dietary levels of isoleucine alone can extend the lifespan and healthspan of adult mice.


• Dietary levels of isoleucine are associated with increased body mass index and increased mortality in humans.


• Resistance exercise training protects mice from protein-induced fat gain.