About
Standardizing cell models is essential for drug discovery and investigating mechanisms influencing disease onset. Using iPSC-derived neurons and glia marks a revolutionary shift in drug discovery, enabling direct study of novel therapeutics on human neurons without relying on primary human tissue. By creating specific neuron and glia subtypes, researchers can delve into disease pathways, comparing edited to control cell lines to aid in developing therapeutics to treat those diseases.

To accelerate the drug discovery workflow focused on curing neurodegenerative and neuro-related diseases, Synthego and BrainXell’s partnership is streamlining this workflow by leveraging Synthego’s CRISPR expertise and BrainXell’s mastery of working with iPS cells and neurons to make curing those diseases within reach.

Key learning objectives will include:

  • Synthego’s CRISPR-based ECLIPSE™ platform capabilities and its design for high-throughput generation of knock-in iPS cell models.

  • BrainXell’s extensive abilities take iPS cell models to differentiated neurons to efficiently run complex assays with ease.

  • Two Examples:

    • Synthego played a pivotal role in the iPSC Neurodegenerative Disease Initiative (iNDI) spearheaded by the National Institutes of Health (NIH) by generating over 264 clones, encompassing 22 gene targets with 12 variants each, all within a remarkable timeframe of under six months.

    • BrainXell’s power to easily create disease models like APOE E4/E4 and TREM2 edited lines in cortical glutamatergic neurons, cortical astrocytes, and microglia which could be used to perform complex functional assays.



Register To Watch Recording
First Name*
Last Name*
Email Address*
Organization / Company*
Job Title*
Country / Region*
Main Application Area*
Research Area(s)*
Immuno-oncology
CRISPR Methods
Neuroscience
Cancer
Immunology
Genetic Disease
Developmental Biology
Infectious Disease
Agriculture Biology
COVID-19
Cardiovascular Disease
Epigenetics
Other Research Areas
utm_bmcr_source
Registration Terms
This event is hosted by the Scientist.com family of companies. Specific brands and sites associated with this event include InsideScientific. By registering and participating, you acknowledge that your personal data will be processed by the webinar platform (BigMarker) and Scientist.com. You also agree to receive email communication from InsideScientific about this webinar and other programs of similar nature. The sponsors of this webinar are Synthego and BrainXell; by registering and participating, you acknowledge that your data will be processed in accordance with Synthego's and BrainXell's respective privacy policies. You may receive email communication from Synethego and/or BrainXell about this webinar and programs of similar interest. You can withdraw your consent at any time from these communications.
Scientist.com Privacy Policy
✓ Yes, I consent to the registration terms.*
Synthego Privacy Policy
✓ Yes, I consent to the registration terms.*
BrainXell Privacy Policy
✓ Yes, I consent tothe registration terms.*
We use BigMarker as our webinar platform. By clicking Register, you acknowledge that the information you provide will be transferred to BigMarker processing in accordance with their Terms of Service and Privacy Policy.
Powered by BigMarker