Ergothioneine in Clinical Practice: The Most Overlooked Nutrient in Longevity and Resilience*

Ergothioneine (ERGO) is a diet-derived amino-thione concentrated in human tissues via a dedicated transporter (OCTN1/SLC22A4). Despite decades of basic science, ERGO has only recently begun to gain traction in clinical nutrition and longevity education. This webinar positions ERGO as a clinically relevant “redox resilience” nutrient that may help maintain cellular stress physiology in high-demand tissues, with particular relevance to cognition and healthy aging.*
This session reviews a brief history of ERGO discovery and the key chemistry that underpins its thione/thiol adaptive behavior, emphasizing why ERGO should not be considered a generic antioxidant.* We then translate transporter biology into clinical relevance, including tissue distribution patterns (brain, immune, and barrier compartments) and the concept that uptake and retention may increase in normal higher-stress states.
We’ll briefly explain how ERGO may support mitochondrial resilience under stress and influence sulfur-based signaling.* We’ll cover MPST and CSE pathways, and introduce persulfidation as a regulatory layer linking redox balance with metabolic efficiency and cellular endurance. Observational evidence is summarized with clear limitations, followed by a practical review of available human intervention trials, including cognitive and sleep-related outcomes, highlighting what has and has not been demonstrated in humans.*
Finally, a practitioner-ready framework for patient selection will be presented, including dosing for maintenance and short-term higher-dose use, monitoring considerations, and cautious guidance for special populations, including pregnancy and lactation.*

CE INFO - this webinar will offer the following:
1.0 credit of Continuing Professional Education by the PACE program of the Federation of Chiropractic Licensing Boards for DCs.
• 1.0 credit of Continuing Professional Education by the AND for CNSs.
• 1.0 credit of Continuing Professional Education by the AANP for ND's**

• To receive CE credit, you must attend the live event and register using applicable credentials.
• Eligible for CNS, in the US only. PACE approval includes some Canadian territories.
• After attending the live event, you will receive your CE certificate via email within 2-3 weeks.

• SPECIAL NOTE for DCs: PACE is not approved in all states. Please confirm eligibility with your jurisdiction. A list of approved states may be found here: https://pacex.fclb.org/pages/BoardRequirements.php.

This webinar is for healthcare professionals and students only.

* This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
** Oregon ND's must self submit for CE Certification Credit