SAME ECOI PFAS IGE Webinar: Derivation of PFAS RSLs and Toxicity Values

As the regulatory environment surrounding PFAS continues to evolve, understanding the toxicological basis for regulatory values used in human health risk assessment becomes increasingly important. This webinar will provide a general overview of toxicity values, including cancer slope factors, reference doses, and reference concentrations, and their derivation from various data sources. This detailed presentation will provide a comprehensive overview of key topics, including:

Toxicity Values
· Learn about the sources of toxicity values used to evaluate human health risk, including cancer slope factors, reference doses, and reference concentrations.
· Understand the relationship between toxicity values and screening levels, with specific considerations for PFAS within the CERCLA process.

PFAS Risk Assessment
· Explore how DoD incorporates Environmental Protection Agency Regional Screening Levels and specific toxicity values in PFAS CERCLA investigations.
· Address the evaluation of cumulative risk associated with complex mixtures of contaminants such as PFAS, as well as the limitations of such evaluations.

Novel Approaches and Dynamic Regulatory Landscape
· Gain insight into proposed novel approaches for determining PFAS toxicity.
· Discuss potential changes in the dynamic PFAS regulatory landscape. The webinar aims to offer a general understanding of toxicity values, their relevance to human health risk assessments, and current applications for PFAS.