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Advanced In Vitro Technologies to Investigate Therapeutic Impact on the Cancer Immunity Cycle

About This Webinar

Immuno-oncology is a fast-growing branch of science, with an unprecedented number of immunotherapeutics being developed in recent years. It’s not without its challenges though, and researchers must often balance scalability with physiological relevance.

In this webinar, Dr. Rajendra Kumari and Dr. Gera Goverse will discuss the basics of immuno-oncology and how cancer immunotherapies are studied along each step of the cancer immunity cycle. They will provide an overview of in vivo, ex vivo and in vitro assays available, including both traditional as well as novel assays. They will also describe the importance and applications of several technology platforms including flow cytometry, histology, single cell analysis, cytokine profiling, T cell cytotoxicity, and high content imaging, and highlight relevant examples from the literature that used them.

Key learning objectives:

  • What is the cancer immunity cycle? How are the steps of the cycle regulated, and which steps are potential targets for immunotherapeutics?
  • Understand the advantages and limitations of 2D, 3D, in vivo, and ex vivo models
  • Applications of high-content imaging and why HCI analysis is so valuable for preclinical immuno-oncology research

Who can view: Everyone
Webinar Price: Free
Featured Presenters
Webinar hosting presenter
Director of Immuno-Oncology
Trained as an immunologist, Gera has used novel technologies to study the role of
different environmental factors on both the local and systemic immune system to
suppress their responses in inflammatory disorders and in the field of immuno-oncology.

Since joining the team at Crown Bioscience, Gera has executed the design of many
successful immuno-oncology projects to help national and international customers
discover the full potential of their compounds.

Gera is motivated by studying the complex mechanisms of the regulation of the immune
system, exploring tumor-cell interactions and refining ways to stimulate the immune
responses towards the killing of the tumor.
Webinar hosting presenter
Executive Director, Integrated Solutions
After receiving her PhD from the University of Leicester in Molecular Pharmacology, Rajendra joined the Division of pre-clinical Oncology, School of Clinical Sciences, University of Nottingham as a postdoctoral fellow, building expertise in cancer cell biology, model development, in vitro, in vivo, imaging capabilities and molecular pharmacology. In 2005, Rajendra took the role of Project & Business Manager of the Preclinical Oncology Services (PRECOS) contract research business unit and lecturer/assistant professor in 2008. Rajendra was pivotal in the commercialisation of the unit and eventual spinout of PRECOS Ltd in 2010, acting as Chief Operations Officer, Board Director and co-founder. Following the merger with Crown Bioscience in 2013, Rajendra led Crown Bioscience’s European site as CSO & General Manager. In 2018, Rajendra became Global Head of Scientific Communications for all platforms at the company. Rajendra is a member of the American Association of Cancer Research and British Association of Cancer Research and has authored over 40 abstracts and publications.
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