In this presentation, Pr David Livermore (Professor of Medical Microbiology, University of East Anglia, UK) and Dr David Brealey (Critical care consultant, University College London Hospital, UK) will discuss the rationale for empiric antibiotic prescriptions in COVID-19 patients and the current evidence on secondary infections. They will share their experience with the incorporation of a rapid diagnostic assay in the treatment algorithm of COVID-19 patients, and how this impacted patient management. Finally, the experts will present their learnings from the first wave of the pandemic, and share their viewpoints on a potential second wave.