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Integrative Modeling of Biomolecular Complexes

January 31, 2018 at 03:00:00 PM · Edinburgh
About This Webinar

Life is operated at the nanometer scale through orchestrated communications of biomolecules. By dissecting this nanoworld, we can acquire a fundamental understanding of how biological macromolecules function, how they are related to disease-linked pathways and how to design drugs targeting them. This understanding led to the birth and rise of Structural Biology, the study of the structures of biomolecules and their
complexes at atomic resolution.
In this webinar, Dr. Karaca will briefly introduce the basic Structural Biology techniques and the data types acquired with them. This will be followed by a comprehensive explanation of how to incorporate Structural Biology data into biomolecular simulations, especially into docking. Finally, she will talk about her latest research on integrative modeling, recently published in Nature Methods. For more, please see: https://goo.gl/EdUvBq

Agenda
  • Structural Biology
  • Molecular Docking
  • Integrative Modeling
Who can view: Everyone
Webinar Price: Free
Webinar ID: 95e540edfdbd
Featured Presenters
Webinar hosting presenter
Assoc. Prof
Ezgi Karaca is a computational structural biologist with a specialization in integrative modeling and biomolecular dynamics. She completed her bachelor (2006) and master’s degrees (2008) in the Chemical Engineering Department of Boğaziçi University. During this time, she focused on p73’s tumor suppression network and mechanistic interpretation of sumoylation cascade under the supervision of Prof. Dr. Türkan Haliloğlu and Prof. Dr. Ruth Nussinov (NIH). For her Ph.D., she joined the group of Prof. Dr. Alexandre Bonvin (Utrecht University). Her thesis work was dedicated to the incorporation of various types of experimental data into the modeling of biomolecular complexes. This research granted her the title of “Ph.D. student of the year” (2012). After successfully obtaining her Ph.D. degree, she moved to the European Molecular Biology Laboratory Heidelberg, to carry out her postdoctoral studies in the labs of Prof. Teresa Carlomagno (NMR) and Dr. Orsolya Barabas (X-ray Crystallography). There, she worked at the intersection of experimental and computational techniques, where she developed tools to translate in-house experimental data into high-resolution structures of protein-nucleic acid machines (2013-2016). Since 2017, she is the principal investigator of the computational structural biology group at the Izmir Biomedicine and Genome Institute.
Hosted By
BioInfoNet webinar platform hosts Integrative Modeling of Biomolecular Complexes
BioinfoNet is an online community for online bioinformatics meetings initiated by ISCB SC RSG Turkey. This meetings include free webinars and paper clubs.