The molecular information acquisition is gaining strong presence in every aspect of life. Much of this stems from the decreasing cost of DNA sequencing and computational power. Coupled with the data, computational methods are generating waves of interesting results. Interestingly, we are far from making sense of the extremely complicated molecular data. The more data we generate, the more we realize the complexity of the cellular information processing. These developments bring so many exciting opportunities and challenges. In this presentation, I will review different aspects of how triage of genomics, transcriptomics, epigenetics is changing the way we understand how molecular health translates to individual health. I will also review some of the future challenges related to high throughput data acquisition and data analysis.