Special Offer: Get 50% off your first 2 months when you do one of the following
Personalized offer codes will be given in each session
  • Presentation
  • Media
  • Chat

Reconstruction of Signaling Network Topology from Steady State and Dynamic Perturbation Data

August 28, 2014 at 06:30:00 AM · Istanbul 526 views
By BioInfoNet (4.5 stars · 2 reviews )
About This Webinar

The first talk of the Bioinfonet Series will be given by Assoc. Prof. Dr. Tolga Can.

Dr. Can has a bioinformatics research group at one of the Turkey's top notch universities, Middle East Technical University, Computer Engineering Department.

As the ISCBSC RSG Turkey crew, we are proud to invite the bioinformatics research community to this inspirational talk.

"Given a set of proteins of interest in a signaling pathway, a common problem is to elucidate the signaling interactions and the dynamics of these interactions between these proteins. A first step towards an accurate solution is to figure out the underlying network topology; before working out the details of the dynamics of these interactions using biochemistry or structural biology. Several experimental techniques, such as RNAi screens, are designed to infer the structure of signaling networks. Existing solutions, either manual or automated, usually suffer from the scalability problem: they are not practical for signaling networks containing more than 20-30 proteins. In our research group, we target this problem and have developed a couple of algorithms in the past to construct larger scale signaling networks. In my talk, I will first show that reconstructing signaling networks from perturbation data is indeed a difficult problem. I will then propose two heuristics to solve the problem approximately and show that the approximate solutions are biologically acceptable. Finally, I will discuss our recent formulation which utilizes available time series data in reconstruction of the network topology. Our results show that, time series data is very valuable in scaling the solution easily to networks of larger sizes."

In Agenda
  • Signaling Networks
Categories:
BUSINESS & FINANCE EDUCATION & LEARNING NONPROFITS & CAUSES SCIENCE & TECH
Who can view: Everyone
Webinar Price: Free
Featured Presenters
Associate Professor
Department of Computer Engineering
Middle East Technical University
Ankara, Turkey
Hosted By
BioInfoNet webinar platform hosts Reconstruction of Signaling Network Topology from Steady State and Dynamic Perturbation Data
30 reviews
BioinfoNet is an online community for online bioinformatics meetings. This meetings include free webinars and paper clubs. BioinfoNet is facilitating with full support of ISCB RSG.
Conversation
You do not have permission to post to this bulletin.
Zeynep Ö
Dear Attendees and visitor,

Because of a known bug in the system, the presentation starts at roughly 30. minute of the video. Sorry for inconvenience. We will share a cropped version at our youtube channel.

Thank you for your understanding :)
Faisal G
Thanks
Zeynep Ö
Dear participants, in order to gather information about the audience we prepared this form. This data will help as planning ahaed. So it will be great if you could fill this. http://goo.gl/Y14oC8

Thank you!
Registered (35 ) View all
  • F4
  • M4
Attended (18) View all
  • Img_3335_-_version_2
  • Gungorbudak
  • 2014-06-29_18.57.16-5
  • Stringio
  • 20140614_105354_3_2
  • Stringio
  • Open-uri20140128-756-1rinqkz
  • Open-uri20140816-10588-1ehzetb
  • Ntuncbag2
  • Stringio
  • 2e5b572
  • 1910481_10152331050148981_5408658469372198364_n
  • 0cf83d8
  • Open-uri20140828-4235-16r5g9l
  • Img_20140615_153521
  • D3
  • Open-uri20140828-17938-1c16req
  • H6